Assembly and substrate switching of the T3S protein export apparatus in enteropathogenic E. coli KU Leuven
The Type III protein secretion (T3S) pathway is common in Gram-negative pathogens, like enteropathogenic E. coli(EPEC). EPEC can use the T3S machinery, also called injectisome, to deliver virulence factors into the host cell. The injectisome comprises the basal body with a cytoplasm-facing export apparatus channel and a surface-exposed needle. The export apparatus comprises a conical SctR5S4T1export channel, decorated by SctU, and enveloped by ...