Parkinson's disease: identification and validation of PINK1 substrates. KU Leuven
Mutations in the PINK1 gene cause an early-onset familial form of the common neurodegenerative movement disorder Parkinson’s disease. PINK1 is a mitochondrially targeted kinase that regulates multiple aspects of mitochondrial
biology, from oxidative phosphorylation to mitochondrial clearance.
Ten years after its original implication in Parkinson’s disease, several downstream substrates have been identified. However, the ...