Bone marrow derived mesenchymal stem cells are attracted by a multiple myeloma cell-produced chemokine (CCL25) and stimulate myeloma cell expansion through AKT and ERK pathways Vrije Universiteit Brussel
Background. Mesenchymal stem cells (MSCs) are multipotent stem cells that have immunomodulary properties and that produce a variety of hematopoiesis-stimulating cytokines. They can be expanded in vitro at clinical scale and are currently used in several pre-clinical and clinical studies for supporting hematopoiesis and/or controlling graft vs. host disease after hematopoietic stem cell transplantation, for tissue engineering or as gene therapy ...