Bioprocess development for scalable production of Cartilage Intermediate Spheroids - following Quality by Design principles KU Leuven
This PhD project relies on a recent bio-mimetic methodology for in vitro process design inspired by in vivo developmental stages of tissue formation. Aim of the work is to develop and optimize the bioprocess for suspension bioreactor culture of progenitor cells to produce size-controlled µ-aggregate populations with defined chondrogenic properties. Automation aspects will be also considered in order to improve control of final product ...