Projects
Decision making in the presence of uncertainty: Industry 4.0 enabled preventive maintenance KU Leuven
Decision making, accompanied by uncertainty in the quality of available information and the decision’s eventual outcome, plays a central role indaily life. In this dissertation, we explore the value of additional information in maintenance decision making and how best we can utilize available data to enhance such decisions. Specifically, we add to the state-of-the-art in maintenance optimization as facilitated by Industry 4.0 technologies. ...
Pharmacometric models to improve therapeutic drug monitoring of monoclonal antibodies in the treatment of inflammatory bowel diseases KU Leuven
Inflammatory bowel diseases (IBD) are chronic, relapsing, inflammatory conditions of the gastrointestinal (GI) tract. Ulcerative colitis (UC) and Crohn’s disease (CD) are the primary subtypes of IBD. Although the etiology remains incompletely understood, it is generally accepted that IBD is the result of an inappropriate host response to environmental factors in genetically susceptible individuals. In Western Europe, prevalence of UC is ...
Flexible Power Plant Operation in Electricity Systems with High Shares of Renewables KU Leuven
The massive introduction of variable and only partly predictable renewable energy sources (such as wind and solar power) in modern power systems poses challenges regarding the limited flexibility of power plants, cost-efficient electricity market operation and the system’s reliability. This dissertation presents an operational modeling framework, which is afterwards deployed in case studies for the purpose of gaining new or improved insights ...