Deciphering the contribution of progranulin deficient human microglia in the initiation and modification of frontotemporal dementia. University of Antwerp
Frontotemporal dementia (FTD) is the second most common form of dementia. It presents a heterogenous range of neuropathological hallmarks, including aberrant accumulation of TAU, FUS or TDP-43. FTD is also accompanied by inflammatory changes in the brain. Recent data place microglia, the immune cells of the brain, under the spotlight as central player in determining the susceptibility for developing FTD. In this proposal, we aim to define what ...