A combined in vitro and in vivo approach to unravel persister mechanisms in natural isolates of Pseudomonas aeruginosa KU Leuven
Currently, global health is threatened by the emergence of pathogenic bacteria that evade conventional antibiotic treatments. One well‑known cause of therapy failure is the emergence of antibiotic resistance. However, infections can be difficult to eradicate even if bacterial populations appear susceptible to the applied antibiotic. This difficulty can be explained by the presence of, usually, small fractions of antibiotic‑tolerant persister ...