The role of FUS in amyotrophic lateral sclerosis. KU Leuven
Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disorder characterized by the selective death of motor neurons. This progressive motor neuron loss results in muscle weakness, paralysis and ultimately death of the patient, usually within 5 years after the diagnosis. While no familial history is present in the majority of ALS patients, 10 % suffer from a familial variant of the disease (FALS). By far the most studied ...