Infrastructure
When size matters: a platform to study molecular interactions and multimerisation (SIZEMAT) KU Leuven
A system that offers a choice of resolving the samples according to hydrodynamic volume using either size-exclusion chromatography or field-flow fractionation with an online multi-detector system including multi-angle light scattering, dynamic light scattering, UVvisible light absorption, refractometry, and the detection of fluorescence spectra. The requested instrument allows to separate a complex molecular sample according to the size of the comprising molecules, followed by immediate inline characterisation of the molecular weight, shape,
concentration and binding to ...
Nuclear Magnetic Resonance Spectroscopy Platform for Molecular Water Research (NMRCORE) KU Leuven
NMRCORE is a convergent research node operating 3 medium to high field research NMR spectrometers, optimized to investigate different states of water upon confinement in nanoscopic cavities. This IRI proposal aims to allow us to operate as a research infrastructure hub of CMWS. Within the local research program, we envisage the design of a dedicated NMR platform suited for in situ access to all facets of structure, dynamics and interface behavior of water confined in porous hosts. In situ multidiagnostic NMR techniques will be developed and especially an NMR-dielectric coupled cell is ...
Multimodal fluorescence microscopy and nanoscopy platform (MULTI-NANO) KU Leuven
Fluorescence microscopy and super-resolution fluorescence microscopy -nanoscopy- offers the possibility to study in a non-invasive way structures ultimately down to the nanometer scale. The ability to do so dynamically will prove to be an indispensable tool in analyzing the molecular mechanisms and organization of living as well as non-living systems. Technological advances in the microscopy field have now resulted in commercially available microscopes that allow fast imaging with light levels that do not perturb or damage the system at study which is e.g. crucial for living systems. At ...
Interventional X-ray system equipped with 3D rotational angiography for cardiovascular research in preclinical large animal models (INTERVENTIONAL X-RAY) KU Leuven
Current strategies for early treatment of acute coronary
syndromes (i.e. heart attacks) have improved acute survival
but subsequent heart failure and arrhythmias (sudden
cardiac death) are the long-term cause of mortality and
morbidity. Responsible use of large animals as preclinical
translational models remains a cornerstone in
cardiovascular research
and play an irrefutable role in exploratory and validation
research, avoiding a high-risk shortcut from basic research
to randomised clinical trials. In order to be relevant,
translational ...
Nuclear Magnetic Resonance spectrometers (NMR) Ghent University
The NMR Expertise Center (NMR EC) currently (December 2022) has 5 NMR spectrometers of different field strengths going from 300MHz to 700MHz. Each spectrometer is equipped with one or more detection probes that allow to interrogate organic molecules in solution about their molecular structure, behavior in solution, internal dynamics, intermolecular interactions, ... . Examples of these organic molecules include natural and synthesis products, polymers, metabolites, complex peptides, nucleic acids and sugars. Each probe has multiple channels where a diversity of atomic nuclei can be ...
Enabling Nuclear Magnetic Resonance (NMR) spectroscopy for the characterization of small to medium-sized organic molecules at VUB (NMR) Vrije Universiteit Brussel
Distributed System of Scientific Collections (DiSSCo-Vlaanderen) Ghent University
DiSSCo is a new world-class research infrastructure for the physical and digital management of European natural science collections with an overarching management and access policy. To make collections more visible and usable, associated data and media must become more findable, accessible, exchangeable and reusable (FAIR). DiSSCo represents the largest formal agreement ever between natural history museums, botanical gardens, zoos, universities and other institutions with collections, and enables the transformation of a fragmented landscape into an integrated knowledge base. DiSSCo ...
Upright Eclipse Ni-U epifluorescence microscope Ghent University
Epi-fluorescence microscope with workstation and software:
Lenses:
CFI Plan Apochromat UW 2X/CN NA: 0.1 (Brightfield)
CFI Plan Apochromat Lambda D 4X NA: 0.2 (Brightfield, fluorescence, polarization)
CFI Plan Apochromat Lambda D 10X NA: 0.45 (Brightfield, fluorescence, polarisation, dark field, DIC)
CFI Plan Apochromat Lambda D 20X NA: 0.8 (Brightfield, fluorescence, polarisation, DIC)
CFI Plan Apochromat Lambda D 40X NA: 0.95 (Brightfield, fluorescence, polarisation, DIC)
CFI Plan Apochromat Lambda D 100x Oil NA: 1.45 (Brightfield, fluorescence, ...