Projects
Mitochondrial involvement in the regulation of neurotransmission in health and disease. KU Leuven
Thermal evolution during range expansion of the pace-of-life and the mitochondrial phenotype: a complex life cycle perspective KU Leuven
Range expansions toward warmer regions provide natural experiments to study the rapid thermal evolution of the pace-of-life (POL). The POL refers to the alignment along a fast-slow continuum, whereby fast-paced animals have a faster life history and metabolic rate, but an increased sensitivity to oxidative stress and a shorter lifespan. I will study the thermal evolution and plasticity of the POL during the range expansion of the damselfly ...
Analysis of mitochondrial dysfunction in Parkinson disease. KU Leuven
Structural snapshots of transcription initiation process by human and yeast mitochondrial RNA polymerases. KU Leuven
Transcription of genes are highly regulated process. The eukaryotic and bacterial gene transcription are accomplished by multi-subunit RNA polymerases (RNAPs). The mitochondrial genes are transcribed by single-subunit RNAPs. Regardless of differences in details, all RNAPs catalyze transcription initiation by a common sequence of events consisting of (i) promoter-specific recognition, (ii) formation of a transcription bubble, (iii) DNA ...
Unravelling the non-specific mechanisms underlying non-polar narcotic toxicity: mitochondrial effects. University of Antwerp
Nuclear Transfer for female-related infertility and mitochondrial diseases Ghent University
This proposal aims at the (pre-)clinical validation of the novel Nuclear Transfer (NT) technology in
assisted reproductive technology for two specific indications, being (1) female-related infertility and
(2) mitochondrial DNA (mtDNA) diseases. The NT technology involves the transfer of the nuclear
genome from a patient’s diseased or inferior quality oocyte or zygote to a healthy donor counterpart
from which the ...
Understanding mitochondrial function and the role of exogenous ketone supplementation in combating exercise intolerance and chronic fatigue in long COVID. Vrije Universiteit Brussel
term effects (long COVID). The symptoms (mostly fatigue and postexertional symptom exacerbation (PESE)) influence the life of these
patients. The current guidelines for rehabilitation are insufficient and
the pathogenesis is not fully understood. The first aim is to
understand the role of mitochondrial function (MF) in long COVID,
using a ...
Do children born after intracytoplasmic sperm injection have an increased risk of mutations in mitochondrial DNA? Vrije Universiteit Brussel
Mitochondrial mutations: new challenges for resistence management Ghent University
This project aims at analysing the properties and evolution of mitochondrial encoded resistance traits in arthropods. This project offers a rare opportunity to an in depth study of non-Mendelian inheritance under controlled laboratory circumstances in arthropods. The final goal is a thorough evaluation of the resistance risks of QoI inhibitors in a broader context than crop protection and the exploration of processes regulating the evolution ...