Mechanisms underlying increased tolerance of oxidative phosphorylation by fetal liver compared with bone marrow derived hematopoietic stem cells KU Leuven
Additional insights in signals underlying symmetrical self-renewing cell divisions typical for fetal liver (FL) hematopoietic stem cells (HSCs), but not bone marrow (BM) HSCs would be instrumental for designing methods that allow true adult HSC expansion without inducing differentiation or ageing. We recently described that unlike adult HSCs, FL HSCs use oxidative phosphorylation (OxPhos), which might allow their greater expansion. However, ...