Publications
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Cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy in patients with advanced ovarian cancer (OVHIPEC-1) University of Antwerp
Background The OVHIPEC-1 trial previously showed that the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery resulted in improved progression-free and overall survival compared with cytoreductive surgery alone at 4 center dot 7 years of follow-up in patients with stage III epithelial ovarian cancer who were ineligible for primary cytoreduction. We report the final survival outcomes after 10 years of ...
1-or 3-Month DAPT in Patients With HBR With or Without Oral Anticoagulant Therapy After PCI Hasselt University
BACKGROUND The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) in patients on long-term oral anticoagulation (OAC) therapy is still uncertain. OBJECTIVES The aim of this analysis was to assess the effects of 1-vs 3-month DAPT in patients with and those without concomitant OAC included in the XIENCE Short DAPT program. METHODS The XIENCE Short DAPT program enrolled patients with high bleeding ...
Combining PD-1/PD-L1 blockade with type I interferon in cancer therapy University of Antwerp
PD-1 and PD-L1 are crucial regulators of immunity expressed on the surface of T cells and tumour cells, respectively. Cancer cells frequently use PD-1/PD-L1 to evade immune detection; hence, blocking them exposes tumours to be attacked by activated T cells. The synergy of PD-1/PD-L1 blockade with type I interferon (IFN) can improve cancer treatment efficacy. Type I IFN activates immune cells boosts antigen presentation and controls ...
Macrophages in the brain Vrije Universiteit Brussel
The brain plays a pivotal role in the normal functioning of the body, and is thereto organized in specialized compartments that combine brain accessibility with protection. Indeed, permissive brain border regions –including meninges and choroid plexus– allow a necessary degree of communication with the periphery, while sophisticated barriers block unwanted cells and molecules from entering the brain’s functional tissue or parenchyma. Each ...
Influence of biotic interventions on the immune response to vaccines in young and older adults University of Antwerp
Vaccination is the most effective way to confer potent and long-term protection from infectious diseases. However, poorer responses to immunization are common in young adults with sub-optimal immune health and the elderly because of immunosenescence and increased comorbidities. Recent mechanistic studies have highlighted that the microbiota and its compounds modulate many molecular pathways that can influence the host immune system. ...
Modeling the social sustainability in rural communities of developing countries (case study: Bilevar Plain; Kermanshah Province) University of Antwerp
Purpose: Understanding how rural communities meet their needs and enhance their well-being while promoting social cohesion, equitable access to resources and services, and fostering community resilience is of utmost importance when investigating the social sustainability of rural areas. Social dimensions often receive inadequate attention during the appraisal of rural development projects. Consequently, the main aim of this study is to create ...
The role of oxytocin in autism. Neurobiological markers and interventions for socio-communicative impairments in autism KU Leuven
Individuals with Autism Spectrum Disorders (ASD) have difficulties with social communication and interaction. To date, no objective quantitative (bio)marker exists for ASD, thus formal diagnosis is solely based on clinical expertise. In addition, there are no pharmacological interventions available for ASD. Here, we will validate an innovative EEG-based neural tool to quantify socio-communicative sensitivity. Next, we will combine this new tool ...
Competitive intensity in differently regulated men's football leagues: evidence from English premier league and German Bundesliga KU Leuven
Purpose The Premier League (PL) and the Bundesliga (BL) were chosen for this study due to their fundamentally different approaches to ownership regulation and the distribution of media revenues. Regulation in the PL is very liberal if compared to the BL's 50+1-rule. In the BL, the distribution of media revenues is mainly based on past performance, whereas equal distribution is dominant in the PL. The specific aim of this paper was a longitudinal ...
The influence of narrow aortic bifurcation on limb graft patency: a two-center retrospective study KU Leuven
BACKGROUND: Narrow aortic bifurcation (NAB) has been considered as a potential risk factor for graft limb thrombosis after endovascular aortic repair (EVAR). The aim of this study was to compare mid- and long-term outcome of EVAR in patients with NAB and standard aortic bifurcation (SAB). METHODS: Data from patients receiving EVAR were prospectively collected and retrospectively analyzed. In case of angiographic limb stenosis (>50%), ...