Projects
N-nitrosamines in Dry Fermented Sausages: Occurrence and Formation of N-nitrosopiperidine KU Leuven
N</>-Nitrosamines can regularly be detected, although mostly in low concentrations. ...
Mitochondrial mutations: new challenges for resistence management Ghent University
This project aims at analysing the properties and evolution of mitochondrial encoded resistance traits in arthropods. This project offers a rare opportunity to an in depth study of non-Mendelian inheritance under controlled laboratory circumstances in arthropods. The final goal is a thorough evaluation of the resistance risks of QoI inhibitors in a broader context than crop protection and the exploration of processes regulating the evolution ...
Characterization of the in vivo role of MALT1 proteolytic activity in inflammation and immunity Ghent University
Lymphocyte activation plays a critical role in immune responses and a defect results in severe immune deficiencies/lymphoma. The paracaspase MALT1 is of special interest, although the mechanism by which MALT1 triggers NF-kB activation is still largely unclear. The aim of this project is to study, by using newly generated mouse models, (1) MALT1 inactive and (2) MALT1 resistant A20, and also analyze the effect of MALT1 peptide inhibitors.
The in vivo study of signaling pathways involved in cell survival and cell death within the central nervous system Ghent University
NF-kB is a transcriptionfactor which plays a central role in inflammation. The A20 protein is an inhibitor of NF-kB through a negative-feedback loop. Furthermore, FADD, which is usually studied for its role in celldeath signalisation, is also known to excert some NF-kB inhibiting properties. By using tissue-specific knock-out mice for A20 and FADD, their role in neurodegeneration will be studied.
Development of synthetic strategies for phosphono-isoindoles and related heterocyclic phosphonates Ghent University
The study aims at the development of new and straightforward methodologies for a new class of azaheterocyclic phosphonates. The study will elaborate on a new catalyst free phosphono-isoindole synthesis and will concentraet on a reactivity study. Azaheterocyclic phosphonates are studied in order to deveop enzyme inhibitors for the agrochemical (plant growth regulation) and medicinal (anti-invasive) field.
Characterisation and in vivo validation of the therapeutic potential of JAK/STAT antagonists in neuroblastoma Ghent University
Evaluation of JAK/STAT pathway inhibitors on neuroblastoma (NB) cell-lines revealed a dramatic reduction in cell viability in comparison to control cells. Further characterisation of the cellular effects and identification of the actual targets of the tested compounds can provide important insights in the critically deregulated pathways in NB and can implicate a fundamental acquisition for the future treatment of NB.
Novel strategies against infectious diseases KU Leuven
Antiviral drugs are only available against infections with herpesviruses, HIV, hepatitis B and C viruses and the influenza virus. For (m)any other viral infection(s) that pose an important treat to human health (including re-emerging & neglected infections), there are no antivirals available (see also WHO BluePrint list). From time to time, novel viruses emerge with the potential to cause large epidemics andmankind will be largely left ...
Biological characterisation of new molecular forms of chemotactic cytokines: role in inflammation and cancer. KU Leuven
Biological characterisation of new molecular forms of chemotactic cytokines: role in inflammation and cancer.
The first dimension of chemokine heterogeneity is reflected by their discovery and purification as natural proteins. Each of those chemokines attracted a specific inflammatory leukocyte type. With the introduction of genomic technologies, a second wave of chemokine heterogeneity was established by the discovery of putative ...