The role of conserved genetic and epigenetic responses in hypoxiainduced EMT unraveled via the invertebrate model Daphnia. KU Leuven
Cancer is one of the leading causes of death worldwide. Multiple steps are needed for a normal cell to become malignant. One of the important features of cancer cells is the ability to invade and metastasize tissues. Epithelial-to-mesenchymal transition (EMT) is a mechanism cancer cells use to escape from the primary tumor locus. These cells change morphology and loose cell-cell contacts upon invasion. Lack of oxygen in parts of the tumor is ...