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The HUPO Brain Proteome project wish list : summary of the 9th HUPO BPP Workshop 9-10 January 2008, Barbados Ghent University
The Human Brain Proteome Project (HUPO BPP) aims at advancing knowledge and the understanding of neurodiseases and aging with the purpose of identifying prognostic and diagnostic biomarkers, as well as to push new diagnostic approaches and medications. The participating groups meet in semi-annual workshops to discuss the progress, as well as the needs, within the field of proteomics. The 9(th) HUPO BPP workshop took place in Barbados from 9-10 ...
Stem-cell-derived human microglia transplanted into mouse brain to study human disease KU Leuven University of Antwerp Flanders Institute for Biotechnology
Microglia are critically involved in complex neurological disorders with a strong genetic component, such as Alzheimer's disease, Parkinson's disease and frontotemporal dementia. Although mouse microglia can recapitulate aspects of human microglia physiology, they do not fully capture the human genetic aspects of disease and do not reproduce all human cell states. Primary cultures of human microglia or microglia derived from human induced ...
Analysis of the experimental detection of central nervous system-related genes in human brain and cerebrospinal fluid datasets Ghent University
Large-scale and high-throughput proteomics experiments of specific samples provide substantial amounts of identified proteins and peptides, which increasingly find their way into centralized, public data repositories. These data typically have potential beyond the analyses performed by the original authors, and can therefore provide considerable added value by being reused for specific, unexplored enquiries. We here reanalyze two CNS-related ...
The Developing Human Connectome Project Neonatal Data Release KU Leuven
The Developing Human Connectome Project has created a large open science resource which provides researchers with data for investigating typical and atypical brain development across the perinatal period. It has collected 1228 multimodal magnetic resonance imaging (MRI) brain datasets from 1173 fetal and/or neonatal participants, together with collateral demographic, clinical, family, neurocognitive and genomic data from 1173 participants, ...
New approach methods to improve human health risk assessment of thyroid hormone system disruption-a PARC project Vrije Universiteit Brussel University of Antwerp
Current test strategies to identify thyroid hormone (TH) system disruptors are inadequate for conducting robust chemical risk assessment required for regulation. The tests rely heavily on histopathological changes in rodent thyroid glands or measuring changes in systemic TH levels, but they lack specific new approach methodologies (NAMs) that can adequately detect TH-mediated effects. Such alternative test methods are needed to infer a causal ...
Call for participation in the neurogenetics consortium within the Human Variome Project University of Antwerp
The rate of DNA variation discovery has accelerated the need to collate, store and interpret the data in a standardised coherent way and is becoming a critical step in maximising the impact of discovery on the understanding and treatment of human disease. This particularly applies to the field of neurology as neurological function is impaired in many human disorders. Furthermore, the field of neurogenetics has been proven to show remarkably ...
C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes University of Antwerp Flanders Institute for Biotechnology
Transmembrane protein 106B (TMEM106B) is a tightly regulated glycoprotein predominantly localized to endosomes and lysosomes. Genetic studies have implicated TMEM106B haplotypes in the development of multiple neurodegenerative diseases with the strongest effect in frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP), especially in progranulin (GRN) mutation carriers. Recently, cryo-electron microscopy (cryo-EM) studies showed that ...
Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo University of Antwerp
The study of human cortical development has major implications for brain evolution and diseases but has remained elusive due to paucity of experimental models. Here we found that human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), cultured without added morphogens, recapitulate corticogenesis leading to the sequential generation of functional pyramidal neurons of all six layer identities. After transplantation into ...