AIM The aim of this project is to study the role of placental growth factor (PLGF) in the development of portal hypertension and its complications, in the development of cirrhosis and steatosis/NASH. - We will focus on the role of PLGF in the formation of angiogenesis in the mesenterium, of collaterals (shunts) in the peripheral, splanchnic and pulmonary circulation, with also the study of initiating factors such as hypoxia (HIF pathway). The ...