Role of cerebral hypoperfusion in multiple sclerosis (ROCHIMS): study protocol for a proof-of-concept randomized controlled trial with bosentan Vrije Universiteit Brussel KU Leuven
Background: Axonal degeneration is related to long-term disability in patients with multiple sclerosis (MS). The underlying mechanism remains ill understood but appears to involve axonal energetic dysfunction. A globally impaired cerebral blood flow (CBF) has been observed in the normal-appearing white matter (NAWM) of patients with MS, which is probably related to astrocytic overexpression of endothelin-1 (ET-1). Cerebral hypoperfusion has ...
Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion Hasselt University
In vivo evidence for long-term vascular remodeling resulting from chronic cerebral hypoperfusion in mice Hasselt University KU Leuven
Impaired Facial Emotion Recognition in Patients With Ventromedial Prefrontal Hypoperfusion KU Leuven Ghent University
Impaired facial emotion recognition in patients with ventromedial prefrontal hypoperfusion Vrije Universiteit Brussel
Cerebral hypoperfusion Vrije Universiteit Brussel
The exact pathogenesis of multiple sclerosis (MS) is incompletely understood. Although auto-immune responses have an important role in the development of hallmark focal demyelinating lesions, the underlying mechanism of axonal degeneration, the other key player in MS pathology and main determinant of long-term disability, remains unclear and corresponds poorly with inflammatory disease activity. Perfusion-weighted imaging studies have ...
Regional occult hypoperfusion detected by lactate and Sequential Organ Failure Assessment subscores: old tools for new tricks? Vrije Universiteit Brussel
The Role of Cerebral Hypoperfusion in Multiple Sclerosis (ROCHIMS) Trial in Multiple Sclerosis Vrije Universiteit Brussel
Background: Accumulating evidence indicates that mitochondrial energy failure is involved in the progressive axonal degeneration in multiple sclerosis (MS). In patients with MS, it has been shown that both levels of N-acetylaspartate (NAA), which is a marker of axonal mitochondrial energy, and cerebral blood flow (CBF) are reduced in cerebral normal appearing white matter (NAWM). The latter is likely due to the vasoconstrictive action of ...