A general law describing the diffusion of membrane proteins in vivo based on single molecule tracking of membrane proteins in Escherichia Coli. KU Leuven
The ultimate goal of cell biology is to understand how proteins function in real cells and to understand their regulatory mechanisms. To achieve this goal one needs to analyze molecules in their cellular environment and not under idealized test tube conditions. A major difference between in vivo and in vitro conditions is the crowdedness (and associated molecular complexity) of the cytoplasm and biological membranes. As a consequence ...