Publications
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Air Pollution-Induced Placental Alterations: An Interplay of Oxidative Stress, Epigenetics, and the Aging Phenotype? Hasselt University KU Leuven
According to the “Developmental Origins of Health and Disease” (DOHaD) concept, the early-life environment is a critical period for fetal programming. Given the epidemiological evidence that air pollution exposure during pregnancy adversely affects newborn outcomes such as birth weight and preterm birth, there is a need to pay attention to underlying modes of action to better understand not only these air pollution-induced early health effects ...
Methods matter : towards the implementation of label-free MS in the context of hESC histone epigenetics Ghent University
Epigenetics in T-cell acute lymphoblastic leukemia Ghent University
Role of epigenetics in liver-specific gene transcription, hepatocyte differentiation, and stem cell reprogrammation Vrije Universiteit Brussel
Liver toxicity observed during (pre)clinical studies is often a major reason for stopping the development of promising drug candidates. Therefore, the pharmaceutical industry is strongly interested in establishing in vitro screening models to detect hepatotoxicity, and especially chronic liver toxicity, early in the drug development process. However, the currently available liver-based in vitro models suffer from phenotypic instability that ...
Neuroblastoma epigenetics : from candidate gene approaches to genome-wide screenings Ghent University
Epigenetics and its implications for ecotoxicology Ghent University
Epigenetics is implicated in the basis of gender incongruence : an epigenome-wide association analysis Ghent University
Hippocampal and cortical tissue-specific epigenetic clocks indicate an increased epigenetic age in a mouse model for Alzheimer's disease KU Leuven
Epigenetic clocks are based on age-associated changes in DNA methylation of CpG-sites, which can accurately measure chronological age in different species. Recently, several studies have indicated that the difference between chronological and epigenetic age, defined as the age acceleration, could reflect biological age indicating functional decline and age-associated diseases. In humans, an epigenetic clock associated Alzheimer's disease (AD) ...