Projects
Advancing Pediatric Precision Healthcare: Integrating Rapid Metabotyping as a Fundamental Component for 4P Medicine through Source-Driven Metabolome Predictions Ghent University
The rising incidence of pediatric obesity and associated comorbidities has created an urgent need to identify effective therapeutic approaches. To address this problem, source-driven metabolite predictions (based on diet, microbiome, lifestyle and psychological parameters) are proposed, whereby links between metabolite sources and their biomarker signatures can be obtained as a basis towards individualization of treatments (4P principle). To ...
The prenatal exposome and cardiovascular fetal programming: the role of telomere ageing dynamics. Hasselt University
Mitochondriomics as chronicle of early-life ambient air pollution exposure and effects on cardiovascular and cognitive function in childhood Hasselt University
Residential microbial diversity and the development of the immune and neurological systems. Epidemiological studies in children KU Leuven
The range of microbial diversity in indoor dust is proposed as an explanatory mechanism for the development of allergies and may influence the neuropsychological development (ND). Microbial diversity may be determined by the landscape (residential, industrial, agricultural, forest, parks...) and explain the inconsistencies reported in the relationship between green spaces and allergies. In this project, I will evaluate the association of ...
Trajectories of biological and epigenetic ageing from birth onwards to unravel pathways of favourable and unfavourable cardiovascular ageing. Hasselt University
DNA adductomics to study exposomic drivers of disease Ghent University
DNA adducts provide information on the exposure and biological effects of chemical hazards. Hence, the birth of DNA adductomics has not gone unnoticed in the era of exposomics, in which the aim is to study the whole of environmental exposures and biological consequences thereof. This project will apply DNA adductomics in large-scale exposomics for the very first time, to further unravel the determinants of food allergy and esophageal cancer. ...