Replicative stress induced DNA damage response signaling at the crossroad between embryonic stem cells and MYC(N) driven tumours Ghent University
Embryonic stem cells (ESCs) have opened the way to the development of regenerative medicine
(cell therapy). For obvious reasons, preserving the integrity of their genome to avoid cancer
formation is of utmost importance. One possible cause for DNA damage is stress that occurs during
DNA replication (replicative stress). Interestingly, molecular evidence for this process has been
detected in both embryonic stem cells as ...