Projects
Molecular and Cellular Basis for Beta Cell Therapy in Diabetes Vrije Universiteit Brussel
Syntenin, a novel target to counteract cancer progression KU Leuven
Multiple studies indicate that the gain-of-function of syntenin-1 (hereupon referred to as ‘syntenin’) acts as a positive regulator of invasion and metastasis, in various tumors. Consistently, syntenin affects several signaling pathways that are of known relevance for the cancer process. For example, syntenin enhances the fibronectin-induced assembly of integrin-β1 signaling complexes with FAK and c-Src, resulting in the activation of FAK and ...
Development of Computational Methods to Detect Copy Number Alterations in Human Genomes KU Leuven
The chicken cerebellum as a model to study the impact of monocarboxylate transporter 8 deficiency on early brain development KU Leuven
Thyroid hormones (THs) have been characterised as important regulatory factors of vertebrate brain development. As such, they contribute to a wide variety of neurodevelopmental processes that depend on adequate TH levels as well as a correct timing of TH access to distinct neural cells in order to obtain a fully functional brain. This strict regulation of local TH availability is the result of a complex interplay between TH transporters ...
Downstream targets of the metabolic stress sensor SnRK1 - One kinase to rule them all KU Leuven
The evolutionarily conserved SnRK1 (SNF1-related kinase 1) protein kinase (the ortholog of yeast SNF1 and mammalian AMPK) is a major metabolic sensor, allowing acclimatization and energy homeostasis upon changes in energy availability, thereby ensuring plant survival. SnRK1 is activated by low energy stress and repressed by high photosynthetic sugar levels, with the allosteric inhibitor trehalose-6-P acting as a proxy for sucrose supply. To ...
Exploring the biology of heparanase-1 en heparanase-2 in zebrafish: towards novel insights into the molecular mechanism of non-enzymatic mammalian heparanase 'activity' KU Leuven
Translational Molecular Imaging Program for the University of Antwerp: application driven preclinical research. University of Antwerp
Multimodal monitoring of electrophysiological signals in childhood epilepsy and neonatal encephalopathy KU Leuven
</>Summary
EEG records electrical activity in the brain generated by pyramidal cells forming large neuronal networks. EEG monitoring provides a constant assessment of brain function and has 3 major applications in neurological practice. It can be used to appreciate epileptic activity in patients with ...