Calcium-dependent Mechanisms Underlying Beat-to-Beat Variability of Repolarization in Cardiac Hypertrophic remodeling. KU Leuven
The major function of the heart is to continually pump blood through the circulatory system of the entire body to provide nutrients and oxygen whilst removing waste, hence careful regulation is essential. The pump function is driven by electrical signals (action potentials), which are caused as a result of opening and closing of ion channels across the membrane of cardiac myocytes. In mammalian ventricular myocytes the action potential ...