Projects
VIB Grant for Sablina Lab_Period:2022-01-01-2026-12-31 Flanders Institute for Biotechnology
Targeting deubiquitinases in hepatocellular carcinoma: a preclinical assessment of the therapeutic potential in combinatory treatments with tyrosine kinase inhibitors and immune checkpoint inhibition. Ghent University
Advanced hepatocellular carcinoma (HCC), the fate of a majority of HCC patients, is a lethal disease. Systemic therapy using tyrosine kinase inhibitors (TKI) or, since November 2020, the combination of a TKI and an immune checkpoint inhibitor (ICI) only provides a short survival benefit for only a subset of patients and exhibits substantial adverse effects. New treatment options using combination therapies are an urgent unmet clinical need. ...
The role of Kupffer cells in the pathogenesis of hepatocellular carcinoma. Ghent University
The contribution of Kuppfer cells in the pathogenesis of primary liver cancer will be investigated.
Tumor characterization and disease follow-up in multiple myeloma by (epi) genetic profiling using liquid biopsies Vrije Universiteit Brussel
treatment modalities of multiple myeloma (MM). However, MM is still
an incurable disease and patients become refractory to treatment at
some point in the disease evolution. MM is characterized by a patchy
tumor infiltration pattern in the bone marrow, implicating that analysis
of single bone marrow samples can lead to an underestimation of the ...
Neuroendocrine neoplasms University of Antwerp
Synthesis and structure-activity relationship studies of CCR8 agonists as a novel treatment option for autoimmune diseases KU Leuven
Chemokines (chemoattractant cytokines) are a group of small (8 –10 kDa) and predominantly basic proteins that play an important role in the human immune system by regulating the migration and activation of immune cells. These chemokines are divided into three subfamilies based on the location of the first two cysteine (C) residues: CC-chemokines, CXC -chemokines, and CX3Cchemokines (with X being a variable amino acid). C-chemokines are ...
Nanomaterial enhanced immunotherapy for tumor treatment. KU Leuven
Targeting IL4 signaling as a novel therapeutic strategy in the treatment of T-cell acute lymphoblastic leukemia Ghent University
Cure rates in children with T-cell acute lymphoblastic leukemia (T-ALL) approach 90%, due to intensive chemotherapy protocols with glucocorticoids as core components. However, the outcome for patients that fail to obtain a complete hematologic remission upon induction therapy or suffer from relapse remains extremely poor. Upon treatment with chemotherapy, tumor cells tend to acquire survival mechanisms that cause drug resistance. To this end, ...
Origin and molecular drivers of T cell and dendritic cell development in the human thymus. Ghent University
The immune system is our body’s major defense mechanism against invading pathogens, as well as against tumor cells. One of the critical white blood cells that plays a central role in the immune system comprises T lymphocytes. They are generated from blood forming stem cells that undergo a series of discrete developmental stages within a specific organ called the thymus. This organ controls their proper development and this is mediated by ...