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Laryngeal Electroglottography as a Predictor of Laryngeal Electromyography KU Leuven
We evaluate a group of patients who have mobile vocal folds, but have flexible laryngeal examinations suspicious for mild vocal fold paresis. The purpose of this retrospective study is to evaluate if electroglottography (EGG) can predict the probability of having an abnormal laryngeal electromyography (LEMG). Charts of patients evaluated and suspected of having mild vocal fold paresis between August 1, 2004 and March 30, 2006 were reviewed. We ...
Reducing discard mortality in an estuarine trawl fishery Research Institute for Agriculture, Fisheries and Food
A purpose-built, water-filled sorting tray was compared against a conventional dry tray for its utility in reducing discard mortality across a range of conditions in an Australian estuarine penaeid-trawl fishery, including the limits of typical delays in starting sorting (2 vs. 15 min). During nine days of fishing, up to 10 replicate deployments were done for each sorting method and delay. Bycatches (44 389 teleosts comprising 15 species) were ...
Mortality of discards from southeastern Australian beach seines and gillnets Research Institute for Agriculture, Fisheries and Food
Two experiments were done in an Australian estuary to quantify the mortalities and contributing factors for key species discarded during 8 and 9 deployments of commercial beach (or shore) seines and gillnets, respectively. In both experiments, bycatches (2347 individuals comprising 16 species) were handled according to conventional practices and assessed for immediate mortalities before live samples of selected species were discarded into ...
Detection of b7-H4 and p53 in pancreatic cancer - Potential role as a cytological diagnostic adjunct KU Leuven
OBJECTIVES: This study compared p53 expression with B7-H4, a novel cancer biomarker, in pancreatic ductal adenocarcinoma (PDA) resection specimens and in a pilot series of endoscopic ultrasound-guided fine-needle aspirations (EUS-FNAs). METHODS: B7-H4 and p53 expression were evaluated by immunoperoxidase methods in 36 PDA and 15 EUS-FNA specimens and were scored for intensity and proportion of positive cells; cases were then assigned a final sum ...
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes KU Leuven University of Antwerp
Research in autophagy continues to accelerate,(1) and as a result many new scientists are entering the field. Accordingly, it is important to establish a standard set of criteria for monitoring macroautophagy in different organisms. Recent reviews have described the range of assays that have been used for this purpose.(2,3) There are many useful and convenient methods that can be used to monitor macroautophagy in yeast, but relatively few in ...
A phase 2 pilot study of pegfilgrastim and filgrastim for mobilizing peripheral blood progenitor cells in patients with non-Hodgkin's lymphoma receiving chemotherapy KU Leuven
BACKGROUND: Growth factors are frequently used to aid peripheral blood progenitor cell mobilization from bone marrow. This phase 2 study examined the efficacy and safety of pegfilgrastim for mobilizing peripheral blood progenitors cells for autologous transplantation. DESIGN AND METHODS: Patients with non-Hodgkin's lymphoma received one cycle of mobilizing chemotherapy (ifosfamide, carboplatin and etoposide, ICE). Twenty-four hours later they ...
Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation KU Leuven Ghent University
Age-related skeletal muscle sarcopenia is linked with increases in falls, fractures, and death and therefore has important socioeconomic consequences. The molecular mechanisms controlling age-related muscle loss in humans are not well understood, but are likely to involve multiple signaling pathways. This study investigated the regulation of several genes and proteins involved in the activation of key signaling pathways promoting muscle ...
Reduced-intensity conditioning compared with conventional allogeneic stem-cell transplantation in relapsed or refractory Hodgkin's lymphoma: An analysis from the lymphoma working party of the European group for blood and marrow transplantation KU Leuven
PURPOSE: To compare the clinical outcome in terms of nonrelapse mortality (NRM), relapse rate (RR), overall survival (OS), and progression-free survival (PFS) in patients with relapsed Hodgkin's lymphoma (HL) treated with reduced-intensity conditioning (RIC) or myeloablative conditioning followed by allogeneic stem-cell transplantation (alloSCT). PATIENTS AND METHODS: A total of 168 patients with HL undergoing a first alloSCT (RIC, n = 89; ...