Role of the PDGF family in the bone and bone marrow environment KU Leuven
Osteoporosis and non-healing fractures pose an increasing clinical problem worldwide, echoing the need for new osteo-anabolic drugs and improved therapies for bone repair. Platelet-derived growth factor (PDGF) is widely considered for use in clinical orthopedics. A full understanding of the mechanisms of action of the PDGF ligands and receptors in bone homeostasis and fracture healing, as well as their effects within the bone marrow ...