Projects
The MIF/CD74 system as driver of pro-inflammatory B cell functions and secondary neurodegeneration following traumatic spinal cord injury Hasselt University
Effects of immune aging on B cell populations in multiple sclerosis (MS) Hasselt University
The MIF-CD74 system as a driver of pro-inflammatory B cell responses following traumatic spinal cord injury (SCI). Hasselt University
Smart hydrogels for single B cell mining: a smart approach to obtain fully-human antibodies KU Leuven
Monoclonal antibodies (mAb) are the biggest class of biopharmaceuticals used against cancer, inflammatory and autoimmune diseases. As the ability of the human immune system to generate highly specific mAb is unmatched by any man-made approach, several technologies have been developed to generate fully human (FH)-mAb. Among those, single B-cell screening has
emerged as a powerful technique. In this project, two KU Leuven groups will join ...
Defining how a novel B cell population contributes to MS pathology Hasselt University
Understanding how B cell depletion with ocrelizumab affects the immune system in the treatment of MS Hasselt University
The BAFF/APRIL system as an inducer of B cell self-reactivity in spinal cord injury Hasselt University
Spontaneous B cell lymphoma in dogs: state-of-the-art immunophenotyping and proof-of-concept on immunotherapeutic targets to benefit canine patients Ghent University
The number of non-chemoresponsive B cell lymphoma (BCL) canine patients is increasing. Through immunophenotyping of lymph nodes and blood, novel markers will be identified that can improve the diagnosis and prognosis of BCL. The potential of these markers as target for neoantigen immunotherapy will be evaluated via the synthesis of nanobodies, whose efficacy will be investigated in a 3D BCL-model.