Ca2+ signalling in ADPKD: mechanisms and consequences. KU Leuven
Mutations in the genes encoding the polycystin-1 and -2 proteins lead to autosomal dominant polycystic kidney disease (ADPKD), the most common inherited renal disease. Hallmark of the disease is the progressive development of renal cysts that lead to kidney failure. The molecular mechanisms underlying the formation of cysts are of major interest to develop novel strategies for treatment and prevention of ADPKD. Disturbed Ca2+ signaling in ...