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Researcher
Steven Verhelst
- Disciplines:Organic chemistry, Biochemistry and metabolism, Systems biology, Medical biochemistry and metabolism
Affiliations
- Laboratory of Chemical Biology (Division)
Responsible
From1 Jan 2015 → Today - Laboratory of Chemical Biology (Division)
Member
From1 Jan 2015 → Today
Projects
11 - 20 of 26
- Dynamic monitoring of MALT1 paracaspase activity by fluorescently quenched activity-based probesFrom1 Oct 2020 → 15 Oct 2020Funding: BOF - postdoctoral mandates
- Development and in vivo validation of a kit for polyamine transport tracking and quantificationFrom1 Oct 2020 → 30 Sep 2022Funding: IOF - technology validation in lab
- Lighting and decoding the world of serine proteaseFrom10 Sep 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An NMR facility tailored for biomedical researchFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Chemical biology approaches to confirm the druggability of neurodegeneration linked rhomboid proteases.From1 Oct 2019 → 30 Sep 2022Funding: FWO fellowships
- Synthesis and application of probes for serine and cysteine hydrolases and the polyamine transport systemFrom20 Mar 2018 → 20 Mar 2022Funding: BOF - doctoral mandates, BOF - Doctoral projects
- Innovative cleavable linker strategy for mass spectrometry-based elucidation of drug binding sitesFrom1 Jan 2018 → 31 Dec 2020Funding: International Cooperation and Mobility
- How do possible Alzheimer's drugs bind to their target?From1 Jan 2018 → 31 Dec 2018Funding: Private funding of national origin - undefined
- Development of photo-activatable protease inhibitors and activity-based probes and their application in the study of dynamic proteolytic processesFrom1 Oct 2017 → 19 Nov 2020Funding: BOF - Doctoral projects, BOF - doctoral mandates
- Enabling malaria rhomboid proteases as drug targets: usage of molecular cookie cutters to shape novel activity assays and inhibitors.From1 Oct 2017 → 30 Sep 2019Funding: H2020-EU.1.3.- EXCELLEN SCIENCE - Marie Skłodowska-Curie actions
Publications
1 - 10 of 78
- Photopharmacology of Protease Inhibitors: Current Status and Perspectives(2024)
Authors: Steven Verhelst
- Cellular effects of BAPTA: Are they only about Ca2+chelation?(2024)
Authors: Flore Sneyers, Steven Verhelst, Geert Bultynck
- Metabolic support by macrophages sustains colonic epithelial homeostasis(2023)
Authors: Roeland Vanhoutte, Steven Verhelst
Pages: 1931 - + - 4-Oxo-β-Lactams as Novel Inhibitors for Rhomboid Proteases(2023)
Authors: Steven Verhelst
- Chemical Probes for Profiling of MALT1 Protease Activity(2023)
Authors: Steven Verhelst
- Furin-targeting activity-based probes with phosphonate and phosphinate esters as warheads(2023)
Authors: Shanping Ji, Steven Verhelst
Pages: 6498 - 6502 - Ex situ Generation of Thiazyl Trifluoride (NSF₃) as a Gaseous SuFEx Hub(2023)
Authors: Luc Van Meervelt, Steven Verhelst, Ermal Ismalaj, Wim De Borggraeve, Joachim Demaerel
- Mapping Peptide-Protein Interactions by Amine-Reactive Cleavable Photoaffinity Reagents(2023)
Authors: Steven Verhelst
Pages: 25487 - 25495 - Duodenal macrophages control dietary iron absorption via local degradation of transferrin(2023)
Authors: Steven Verhelst
Pages: 2878 - 2890 - Pepstatin-Based Probes for Photoaffinity Labeling of Aspartic Proteases and Application to Target Identification(2023)
Authors: Marc Fransen, Steven Verhelst
Pages: 686 - 692
Patents
1 - 1 of 1