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Continuous-flow synthesis of phenothiazine antipsychotics : a feasibility study
Journal Contribution - Journal Article
The continuous flow synthesis of a model phenothiazine antipsychotic is presented herein, using 3-chloropropionyl chloride as a central building block. The basic phenothiazine-derived scaffold is (atom)-efficiently and mildly synthesized with the aim to present continuous flow technology as a contributor to fast and efficient syntheses of challenging APIs, that are nowadays experiencing supply disruptions and global shortages.
Journal: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Pages: 1350 - 1354