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Publicatie

Continuous-flow synthesis of phenothiazine antipsychotics : a feasibility study

Tijdschriftbijdrage - Tijdschriftartikel

The continuous flow synthesis of a model phenothiazine antipsychotic is presented herein, using 3-chloropropionyl chloride as a central building block. The basic phenothiazine-derived scaffold is (atom)-efficiently and mildly synthesized with the aim to present continuous flow technology as a contributor to fast and efficient syntheses of challenging APIs, that are nowadays experiencing supply disruptions and global shortages.
Tijdschrift: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN: 1434-193X
Issue: 6
Pagina's: 1350 - 1354
Jaar van publicatie:2019