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Nanobody-assisted targeting of sialoadhesin-positive macrophages to improve the treatment of tuberculosis.
Treatment of tuberculosis is severely complicated by the adaptations of its etiological agent, Mycobacterium tuberculosis, allowing survival and replication within the host phagocytes. A better understanding of the host-pathogen interaction and the development of novel treatment strategies are thus critical. We strongly believe in a promising strategy involving the receptor-mediated delivery of therapeutics via the endocytic Sialoadhesin (Sn) receptor present on the surface of phagocytes.
Date:1 Oct 2017 → 30 Sep 2020
Keywords:MYCOBACTERIOLOGY, BACTERIA, MACROPHAGES
Disciplines:Microbiology, Systems biology, Laboratory medicine
Project type:Collaboration project