Researcher
Davie Cappoen
- Keywords:Chemistry (incl. biochemistry)
- Disciplines:Analytical chemistry, Inorganic chemistry, Macromolecular and materials chemistry, Medicinal and biomolecular chemistry, Organic chemistry, Physical chemistry, Sustainable chemistry, Theoretical and computational chemistry, Other chemical sciences, Biochemistry and metabolism, Other biological sciences, Other natural sciences
Affiliations
- Laboratory for Microbiology, Parasitology and Hygiene (LMPH) (Research group)
Member
From1 Apr 2014 → 14 Nov 2022
Projects
1 - 9 of 9
- RNA biomarkers discovery for ultra-fast drug synergy and susceptibility testing in the mycobacterium avium complex.From1 Jan 2020 → 31 Oct 2020Funding: BOF - doctoral mandates
- Towards the realization of a structural biology platform at the University of Antwerp: The Mosquito Xtal3 crystallization robot as the missing link.From1 Jan 2020 → 31 Dec 2021Funding: BOF - scientific equipment program
- Exploitation of key enzymes of the mycothiol biosynthesis to improve treatment of mycobacterium avium complex infections.From1 Nov 2019 → 31 Oct 2023Funding: FWO Strategic Basic Research Grant
- Progress new assets (one pre-new molecular entity and one first-time-in-human start) for tuberculosis that act synergistically with bedaquiline, cytochrome bc or cytochrome bd inhibitors (RespiriTB).From1 May 2019 → TodayFunding: H2020-EU.3.1. - SOCIETAL CHALLENGES - Health, demographic change and wellbeing
- Development of a comprehensive platform for targeting redox homeostasis in Mycobacterium tuberculosis.From1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Nanobody-assisted targeting of sialoadhesin-positive macrophages to improve the treatment of tuberculosis.From1 Oct 2017 → 30 Sep 2020Funding: FWO fellowships
- Elucidation of the octahydrobenzo[j]phenantridinediones as putitive redox cyclers in Mycobacterium tuberculosis.From1 Apr 2016 → 31 Mar 2017Funding: BOF - Other initiatives
- Biological evaluation of 1,3-diaryltriazenes and their mechanism of action on Mycobacterium tuberculosis.From1 Feb 2016 → 5 Jan 2020Funding: FWO Strategic Basic Research Grant
- Elucidating the mechanism of action of octahydrobenzo[j] phenanthridinediones as novel potent antimycobacterialcompounds.From1 Oct 2014 → 30 Sep 2017Funding: FWO fellowships
Publications
1 - 10 of 41
- A high-throughput target-based screening approach for the identification and assessment of Mycobacterium tuberculosis mycothione reductase inhibitors(2024)
Authors: Natalia Smiejkowska, Lauren Oorts, Linda De Vooght, Rob Geens, Henri-Philippe Mattelaer, Koen Augustyns, Sergei V. Strelkov, Dirk Lamprecht, Koen Temmerman, Yann Sterckx, et al.
Pages: 1 - 22 - Expanding the squaramide library as mycobacterial ATP synthase inhibitors(2023)
Authors: Jan Chasák, Lauren Oorts, Milan Dak, Veronika Šlachtová, Václav Bazgier, Karel Berka, Linda De Vooght, Natalia Smiejkowska, Laurence Van Moll, Davie Cappoen, et al.
Pages: 1 - 18 - Design, synthesis, and antimycobacterial evaluation of novel tetrahydroisoquinoline hydrazide analogs(2023)
Authors: Boddupalli Venkata Siva Kumar, Yogesh Mahadu Khetmalis, Adinarayana Nandikolla, Banoth Karan Kumar, Sankaranarayanan Murugesan, Davie Cappoen, Kondapalli Venkata Gowri Chandra Sekhar
Pages: 1 - 13 - Inhibition of bacterial adhesion and biofilm formation by seed-derived ethanol extracts from **Persea americana** Mill(2022)
Authors: Silvia del Carmen Molina Bertrán, Lianet Monzote, Davie Cappoen, Julio Cesar Escalona Arranz, Mario Juan Gordillo Pérez, Annarli O. Rodríguez-Ferreiro, Idelsy Chill Nuñez, Claudina Perez Novo, Daniel Méndez, Paul Cos, et al.
Pages: 1 - 13 - Novel heterocyclic hydroxamates as inhibitors of the mycobacterial zinc metalloprotease Zmp1 to probe its mechanism of function(2022)
Authors: Milan Dak, Veronika Slachtova, Marek Sebela, Vaclav Bazgier, Karel Berka, Natalia Smiejkowska, Lauren Oorts, Davie Cappoen, Lucie Brulikova
Pages: 1 - 15 - Structural basis of cysteine ligase MshC inhibition by cysteinyl-sulfonamides(2022)
Authors: Luping Pang, Stijn Lenders, Evgenii M. Osipov, Stephen D. Weeks, Jef Rozenski, Davie Cappoen, Sergei V. Strelkov, Arthur Van Aerschot
Pages: 1 - 15 - Design, synthesis and biological evaluation of benzo-[d]-imidazo-[2,1-b]-thiazole and imidazo-[2,1-b]-thiazole carboxamide triazole derivatives as antimycobacterial agents(2022)
Authors: Surendar Chitti, Davie Cappoen, Adinarayana Nandikolla, Yogesh Mahadu Khetmalis, Paul Cos, Banoth Karan Kumar, Sankaranarayanan Murugesan, Kondapalli Venkata Gowri Chandra Sekhar
Pages: 22385 - 22401 - Design, synthesis and biological evaluation of novel spiro-[chroman-2,4 '-piperidin]-4-one analogs as anti-tubercular agents(2022)
Authors: Surendar Chitti, Adinarayana Nandikolla, Yogesh Mahadu Khetmalis, Boddupalli Venkata Siva Kumar, Banoth Karan Kumar, Sankaranarayanan Murugesan, Davie Cappoen, Kondapalli Venkata Gowri Chandra Sekhar
Pages: 1 - 9 - Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors(2021)
Authors: Dries De Ruysscher, Luping Pang, Stijn M.G. Lenders, Davie Cappoen, Paul Cos, Jef Rozenski, Sergei V. Strelkov, Stephen D. Weeks, Arthur Van Aerschot
- Differential induction pattern towards classically activated macrophages in response to an immunomodulatory extract from Pleurotus ostreatus mycelium(2021)
Authors: Gabriel Llauradó Maury, Humberto Morris-Quevedo, Annick Heykers, Ellen Lanckacker, Davie Cappoen, Peter Delputte, Wim Vanden Berghe, Zelen Salgueiro, Paul Cos