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Mechanism of infection of sialoadhesin (Sn)-positive macrophages with respiratory syncytial virus (RSV) and its implications for inflammation and immune pathology during bronchiolitis.
Respiratory syncytial virus (RSV) is the major cause of bronchiolitis, itself the commonest single cause of hospitalization during infancy. In older children and in adults, RSV is associated with acute exacerbations of both asthma and chronic obstructive pulmonary disease (COPD). Following the infection of ciliated epithelial cells, the manifestations of bronchiolitis are caused by a combination of viral cytotoxicity and the uncontrolled immune response to infection.
Date:1 Jan 2014 → 31 Dec 2017
Keywords:RESPIRATORY SYNCYTIAL VIRUS (RSV), SIGLEC, MACROPHAGES
Disciplines:Microbiology, Systems biology, Immunology, Laboratory medicine