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Organisation
Translational Research in GastroIntestinal Disorders
Division
Main organisation:Department of Chronic Diseases and Metabolism
Lifecycle:1 Jul 1977 → Today
Organisation profile:
- Neuromodulation of the intestinal immune system
- Immunomodulation of afferent nerve function and visceral hypersensitivity
- Intestinal macrophage phenotyping
- Pathophysiology and treatment of irritable bowel syndrome
- Pathophysiology of postoperative ileus
- Pathophysiology of gastroesophageal reflux disease
- Pathophysiology and treatment of achalasia
- Neuron-glial interactions in the ENS
- Developmental aspects of ENS functionality
- ENS in neurodegenerative and GI disorders
- Second harmonic imaging in neuroscience
- Advanced microscopy
- Nutrient sensing in the gut
- Role of peripheral clock genes in the circadian regulation of gut peptide release
- Role of gastrointestinal peptides and their receptors in the regulation of food intake and gastrointestinal motility
- Ghrelin as a therapeutic target
- Development of analytical tools to analyse the bacterial colonic metabolism
- Evaluation of strategies to modulate bacterial colonic fermentation
- Impact of bacterial colonic fermentation on gut health and systemic health
- Contribution of bacterial colonic fermentation to the pathophysiology of disorders
- Impact of bariatric surgery on bacterial colonic fermentation
- Psychobiological mechanisms of gastrointestinal sensitivity and symptom perception in health and functional GI disorders
- Gut-Brain signaling mechanisms in the control of appetite and food intake in health and food intake disorders
- Influence of subliminal nutrient- and microbiota-induced gut-brain signals on psychological processes and disorders
- Intestinal immune tolerance
- Immunomodulatory role of enteric glia and neurons
- Pathophysiology of food allergy
- Enteric nervous system and inflammation
- Therapeutic drug monitoring in Inflammatory Bowel Diseases
- Pharmacogenetic analysis of factors involved in long-term response to biologicals in Inflammatory Bowel Diseases
- Role of the microbiome, intestinal barrier and immune system in the pathogenesis of Inflammatory Bowel Diseases
- intestinal organoid models in Inflammatory Bowel Diseases
- Normal and abnormal motor activity of oesophagus, stomach, small intestine, colon and anorectum
- Endocrine, paracrine and neurocrine peptide-untreated control mechanisms of gastrointestinal function
- Clinical pharmacology of gastro-intestinal diseases
- Computer analysis of manometric and electromyographic recordings and of long-term pH and pressure measurements in oesophagus
- In vivo and in vitro studies of smooth muscle activity
- Intestinal perfusion studies
Keywords:Gastro-intestinal diseases, Physiopathology, Motility, Breath tests, Peptides, Neurophysiology, TARGID, Endocrinology, Gut-brain interactions, Inflammatory bowel diseases, enteric nervous system, microscopy, Immunology
Disciplines:Endocrinology and metabolic diseases, Gastro-enterology and hepatology, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences