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Project
Nanobody-assisted manipulation of the tumor suppressor p53.
The tumor suppressor and transcription factor p53 plays a key role in cell cycle regulation, apoptosis and senescence and is frequently inactivated in human tumors. Nanobodies against p53 are generated and characterized, in vitro and in vivo. These nanobodies are subsequently utilized to manipulate the activity of p53 in cells in terms of intracellular localization and activity.
Date:1 Oct 2010 → 5 Jan 2016
Keywords:nanobody, p53, tumor suppressor
Disciplines:Transport phenomena, Oncology, Chemical product design and formulation, Immunology, Process engineering, Morphological sciences, Catalysis and reacting systems engineering, General chemical and biochemical engineering, Separation and membrane technologies, Other (bio)chemical engineering