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Project
Role of intestinal barrier dysfunction for the pathogenesis of spondyloarthritis
Patients with spondyloarthritis (SpA), a chronic inflammatory rheumatic disease, usually present with an altered composition of intestinal microbiota (dysbiosis). We want to investigate how dysbiosis influences gut epithelial integrity and the subepithelial immune system. Furthermore we will correlate the local effects of dysbiosis with biomarker profiles, acting as surrogate indicators of gut inflammation and bacterial translocation.
Date:1 Oct 2018 → 30 Sep 2022
Keywords:spondyloarthritis, mucosal barrier, bacterial dysbiosis, gut inflammation
Disciplines:Palliative care and end-of-life care, Regenerative medicine not elsewhere classified, Other health sciences not elsewhere classified, Laboratory medicine not elsewhere classified, Other clinical sciences not elsewhere classified, Orthopaedics not elsewhere classified, Other translational sciences not elsewhere classified, Other basic sciences not elsewhere classified, Immunology not elsewhere classified, Other medical and health sciences not elsewhere classified, Other paramedical sciences not elsewhere classified, Adaptive immunology, Autoimmunity, Nursing not elsewhere classified