Organisation
Laboratory of Computational Biology (VIB-KU Leuven)
Division
Research in the Laboratory of Computational Biology is focusing on gene and genome regulation, with applications in Drosophila and cancer, and on integrative genomics, developing computational methods for genomic data integration and analysis of next-generation sequence data.
Current researchers
1 - 10 of 21 results
- Stein Aerts (Responsible)
- Darina Abaffyová (Member)
- Stein Aerts (Member)
- Sara Aibar Santos (Member)
- Cas Blaauw (Member)
- Carmen Bravo González-Blas (Member)
- Florian De Rop (Member)
- Seppe De Winter (Member)
- Hannah Dickmänken (Member)
- Sam Dieltiens (Member)
Projects
1 - 10 of 64
- Understanding gene regulation in a whole animal: From building a regulatory atlas to decoding gene regulation with deep learningFrom10 Jan 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- SpaceTimeOmics: combining high-throughput spatial omics with AI to model gene regulation in space and timeFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Interpretation of genomic regulatory variation in the human brain and Parkinson’s Disease by integrating deep learning with single-cell multi-omicsFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Deep learning based synthetic design and massively parallel reporter assays to characterize and exploit cell type specific enhancersFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Enhancer-AI: AI-driven modelling and design of cell type specific enhancers for gene therapyFrom1 Oct 2023 → TodayFunding: FWO Strategic Basic Research (SBO)
- Deep learning solutions for deciphering gene regulation in the human brainFrom7 Mar 2023 → TodayFunding: FWO Strategic Basic Research Grant
- The role of smORF encoded polypeptides in lager beer fermentationFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Applications of deep learning for cancer genomicsFrom1 Jan 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Evolution of the genomic regulatory code underlying neuronal diversityFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
Publications
1 - 10 of 177
- HIGH-THROUGHPUT SEQUENCING OF THE HUMAN HEPATIC PROGENITOR CELL NICHE REVEALS DIFFERENT SIGNALLING PATHWAYS DEPENDING ON THE UNDERLYING CHRONIC LIVER DISEASE(2015)
Authors: Olivier Govaere, Jasper Wouters, Wouter Van Delm, R van Eijsden, An Ceulemans, Werner Van Steenbergen, Diethard Monbaliu, Frederik Nevens, Tania Roskams
Pages: S239 - S239 - Combined Proteomics and Transcriptomics Identifies Carboxypeptidase B1 and Nuclear Factor κB (NF-κB) Associated Proteins as Putative Biomarkers of Metastasis in Low Grade Breast Cancer(2015)
Authors: Hana Imrichova
Pages: 1814 - 1830 - The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene(2016)
Authors: Jasper Wouters, Joost van den Oord
- Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma(2020)
Authors: Jasper Wouters, Joost van den Oord
- Cancer stem cells in cutaneous melanoma(2009)
Authors: Jasper Wouters, Joost van den Oord, Hugo Vankelecom
Pages: 225 - 235 - Evidence for DNA-Binding Domain-Ligand-Binding Domain Communications in the Androgen Receptor(2012)
Authors: Christine Helsen, Vanessa Dubois, Annelien Verfaillie, Marc De Maeyer, Frank Claessens
Pages: 3033 - 3043 - CD45 antigen negativity in T-lineage ALL correlates with PTPRC mutation and sensitivity to a selective JAK inhibitor(2015)
Authors: Stein Aerts, Ellen Geerdens, Jan Cools
Pages: 884 - 7 - Plasma cells in primary melanoma. Prognostic significance and possible role of IgA(2016)
Authors: Francesca Bosisio, Jasper Wouters, Marguerite Stas, Joost van den Oord
Pages: 347 - 58 - BNIP3 promotes HIF-1α-driven melanoma growth by curbing intracellular iron homeostasis(2021)
Authors: Matteo Rossi, Chris Van den Haute, Maria Livia Sassano, Abhishek Garg, Francesca Bosisio, Jasper Wouters, Peter Vangheluwe, Wim Annaert, Johan Swinnen, Joost van den Oord, et al.
- A Functional In Situ Approach to TILs in Melanoma: A Critique on the Current Morphological Classification(2016)
Authors: Francesca Bosisio, Jasper Wouters, Nathalie Volders, Marguerite Stas, Joost van den Oord
Pages: 126A - 126A