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Entry of feline infectious peritonitis virus in blood monocytes Ghent University
Feline coronaviruses occur in two virulence variants of which the feline infectious peritonitis virus (FIPV) is the most threatening. It causes a monocyte-derived viremia that leads to a progressive vasculitis and is mostly fatal for the infected cat. There is no effective treatment available. To address this matter, an improved knowledge of the pathogenesis of FIPV is needed. The process of viral entry is an attractive target for the ...
Sialoadhesin and CD163, a dynamic duo involved in porcine reproductive and respiratory syndrome virus entry in macrophages and possible targeting molecules Ghent University
The porcine reproductive and respiratory syndrome virus (PRRSV), which is spread across swine-producing countries, is the economically most important viral pig disease. To further improve PRRSV-management tools, knowledge is required on essential aspects of PRRSV’s life cycle. Much effort is already put into the investigation of PRRSV entry, with an important milestone being identification of the siglec sialoadhesin as a macrophage-restricted ...
The CD147 protein complex is involved in entry of Chikungunya virus and related alphaviruses in human cells Ghent University Institute of Tropical Medicine University of Antwerp
Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry Ghent University
Intriguing interplay between feline infectious peritonitis virus and its receptors during entry in primary feline monocytes Ghent University
Heat shock protein 70 (Hsp70) mediates Zika virus entry, replication, and egress from host cells Institute of Tropical Medicine
Zika virus (ZIKV) is a historically neglected mosquito-borne flavivirus that has caused recent epidemics in the western hemisphere. ZIKV has been associated with severe symptoms including infant microcephaly and Guillain-Barré syndrome, stimulating interest in understanding factors governing ZIKV infection. Heat shock protein 70 (Hsp70) has been shown to be an infection factor for multiple viruses, leading us to investigate the role of Hsp70 ...
Emerging options for interfering with influenza virus entry and replication KU Leuven
Influenza viruses are highly contagious respiratory pathogens with considerable medical and socio-economical burden, whether in the context of the seasonal influenza epidemics or the unpredictable, yet potentially, severe pandemics. The current influenza vaccines require annual updating and provide only partial protection. Hence, antiviral drugs are an essential component in the prevention and treatment of influenza virus infections. At the ...
The role of DC-SIGN and the mode of action of entry inhibitors in dengue virus infection KU Leuven
Dengue virus can be considered as the most important emerging mosquito-borne virus in the world. This RNA virus is only transmitted by a vector, the Aedes aegypti and the Aedes albopictus mosquito. Due to a lack of vector control, massive urbanization and deforestation, global warming and an increase in the international transport, the virus and its vector is spread all over the world. Nowadays, 3.6 billion people are at risk of getting infected ...
Entry inhibitors for human respiratory virus SARS-CoV-2. KU Leuven
Despite the clear success of the administered COVID-19 vaccines, we still cannot control the spread of SARS-CoV-2, as evidenced by the current circulation of the highly contagious Omicron variant. This highlights the need to continue with the development of effective broad-spectrum antivirals that can be used to rapidly diminish viral spread when an epidemic with a (re-)emerging virus occurs. Candidate SARS-CoV-2 inhibitors should show broad ...