Study of the role of electrically silent voltage-gated potassium channels in the insulin secretion of the pancreas. University of Antwerp
The insulin secretion in the pancreas is highly regulated by ion channels. When the plasma glucose concentration increases, the membrane of the ¿-cell depolarizes, which leads to insulin secretion. The repolarization of the ¿-cell is caused by a slowly inactivating, delayed rectifier current, IDR, resulting in an inhibition of insulin secretion. It was shown by a dominant-negative knockout strategy that Kv2 subunits contribute approximately ...