Projects
Genetic and mtDNA contributions to early cardiovascular ageing and disease: a population study KU Leuven
Heart failure (HF) is a progressive disorder that begins with cardiovascular risk factors, proceeds to asymptomatic maladaptive left ventricular (LV) remodelling and dysfunction, and then evolves into clinically overt HF and disability. The genetic and molecular drivers that underlie progressive cardiac dysfunction and remodelling are only partially understood.
The progression of LV dysfunction is associated with changes in cardiac ...
An integrated genetic and functional approach towards understanding the complex etiology of Alzheimer's disease. University of Antwerp
Genetic history and health in Medieval Europe with the Belgian town of Sint-Truiden as a model KU Leuven
The cross-talk between genomics and humanities in the last decade has revitalized the interdisciplinary study of human past and enables us to address now ever wider range of questions about migration, social structure and health of our ancestors. We can ask questions about them that could not be answered before. While ancient DNA studies have substantially changed our perspectives on European Neolithic and Bronze Age, less progress has been ...
Charting the genomic landscape of hybridisation and genetic introgression across the Lake Malawi cichlid adaptive radiation. University of Antwerp
Disecting bacterial persistence through experimental evolution: memory, persister physiology and the link with genetic resistance KU Leuven
A rapidly growing number of patients succumb to bacterial infections for which effective treatment is lacking. The major culprit of this lurking worldwide health crisis is the growing ability of bacteria to cope with antibiotic stress. Due to their high reproduction rates and vast population sizes, bacteria exhibit an enormous potential for evolutionary adaptation. As a consequence, antibiotic survival strategies emerge and spread at ...
Development of Artificial Genetic Systems for Therapeutic Applications KU Leuven
Deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) are among the most remarkable biomolecules occurring in nature, since they store and transfer all genetic information using only four letters (G, C, A & T or U). In the last 60 years, since the discovery of the structure of nucleic acids, numerous chemically modified nucleosides and nucleotides have been produced and incorporated into oligomeric sequences either by chemical or ...