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Estimation of safety performance functions for urban intersections using various functional forms of the negative binomial regression model and a generalized Poisson regression model Hasselt University
Intersections are established dangerous entities of a highway system due to the challenging and unsafe roadway environment they are characterized for drivers and other road users. In efforts to improve safety, an enormous interest has been shown in developing statistical models for intersection crash prediction and explanation. The selection of an adequate form of the statistical model is of great importance for the accurate estimation of crash ...
Long-term safety and efficacy of acotiamide in functional dyspepsia (postprandial distress syndrome)results from the European phase 3 open-label safety trial KU Leuven
BACKGROUNDS: Acotiamide is a novel acetylcholinesterase inhibitor for treatment of postprandial distress syndrome (PDS) symptoms of functional dyspepsia (FD). This European phase 3 open-label safety trial has been conducted to evaluate the long-term safety of acotiamide and explore the efficacy of acotiamide on PDS symptoms using the validated LPDS, quality of life using SF-36 and SF-NDI, and work productivity using WPAI. METHODS: FD-PDS ...
Efficacy and safety of spore-forming probiotics in the treatment of functional dyspepsia: a pilot randomised, double-blind, placebo-controlled trial Hasselt University KU Leuven Ghent University
Background Current treatments for functional dyspepsia have limited efficacy or present safety issues. We aimed to assess spore-forming probiotics in functional dyspepsia as monotherapy or add-on therapy to long-term treatment with proton-pump inhibitors. Methods In this single-centre, randomised, double-blind, placebo-controlled pilot trial that took place at University Hospitals Leuven (Leuven, Belgium), adult patients (>= 18 years) with ...
A model-driven engineering framework to support the functional safety process University of Antwerp
The design of safety-related systems traditionally has long and costly development cycles due to the highly manual safety engineering process, which is guided by industry standards. In this paper, we present a modelling framework that supports DevOps principles of continuous testing and fast development iterations for the design of safety-critical systems. We show how modelling can help introducing DevOps in the context of functional safety ...
Analysis of Effects induced by EM disturbances on COTS Devices, from an EM Security and Functional Safety perspective KU Leuven
Developments in System Safety Engineering contains papers presented at the twenty-fifth annual Safety-critical Systems Symposium, held in Bristol, UK, in February 2017. The Symposium is for engineers, managers and academics in the field of system safety, across all industry sectors, so the papers making up this volume offer wide coverage of current safety topics, and a blend of academic research and industrial experience. They include both ...
Reducing Functional Safety and Other Risks Due to EM Disturbances: IEEE, Standard 1848 KU Leuven
© 2018 IEEE. IEEE Standard 1848 (draft) deals with the problem of managing safety and any other kinds of risks that could be caused by electromagnetic disturbances. It is impractical to test digital hardware or software sufficiently thoroughly for the low levels of risk required for functional safety-related applications, so this is the first of a new type of EMC standard which has requirements that go well beyond immunity testing. This paper ...
Functional Safety Standard's Techniques and Measures in light of Electromagnetic Interference KU Leuven
Everyday modern electronic programmable systems are performing more and more safety-critical tasks. Due to electromagnetic interference (EMI), these systems potentially violate their predefined safety goals. Appropriate actions must be taken to ensure the system's integrity. This paper looks at proposed safety standard techniques in the light of EMI. Redundancy and error detection and correction schemes are not only reviewed, but recommendations ...
In Vivo Transplantation of Enteric Neural Crest Cells into Mouse Gut; Engraftment, Functional Integration and Long-Term Safety KU Leuven
Enteric neuropathies are severe gastrointestinal disorders with unsatisfactory outcomes. We aimed to investigate the potential of enteric neural stem cell therapy approaches for such disorders by transplanting mouse enteric neural crest cells (ENCCs) into ganglionic and aganglionic mouse gut in vivo and analysing functional integration and long-term safety.