Site-Selective Derivatization and Cyclization of Peptides by On-Resin Metal-Catalyzed C-H Activation. KU Leuven
Sustainable Chemistry for Metals and Molecules, Universidad de La Habana
This research project aims at developing innovative procedures for the derivatization of oligopeptides. It combines on-resin multicomponent reactions, peptide couplings and metal-catalyzed C-C bond forming reactions, into an effective methodology for the site-selective derivatization of solid-supported (pseudo)peptides. Three main solid-phase protocols will be developed: site-selective arylation of peptides by Pd-catalyzed C-H activation using ...