Circulating cell-free DNA as an alternative gateway to the genetic features of multiple myeloma and as a surrogate marker for disease burden in multiple myeloma. KU Leuven
This research project explores the research hypothesis that circulating cell-free DNA(ccfDNA) can serve as a minimally-invasive substrate to remotely investigate the genome of the malignant plasma cells in multiple myeloma (MM). We will extensively validate the detection of copy number variations in ccfDNA, by paired analysis of DNA from purified plasma cells by FISH, arrayCGH and low pass sequencing by next-generation sequencing with a ...