Publications
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Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset. Flanders Institute for Biotechnology University of Antwerp KU Leuven Vrije Universiteit Brussel
Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort. Flanders Institute for Biotechnology Vrije Universiteit Brussel KU Leuven University of Antwerp
Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery KU Leuven
The number of agents that are potentially effective in the adjuvant treatment of locally advanced resectable colon cancer is increasing. Consequently, it is important to ascertain which subgroups of patients will benefit from a specific treatment. Despite more than two decades of research into the molecular genetics of colon cancer, there is a lack of prognostic and predictive molecular biomarkers with proven utility in this setting. A secondary ...
A self-tuning genetic algorithm with applications in biomarker discovery Hasselt University KU Leuven
Recent developments in the field of -omics technologies brought great potential for conducting biomedical research in very efficient manner, but also raised a plethora of new computational challenges to be addressed. Extremely high dimensionality accompanied with poor signal-to-noise ratio and small sample size of data resulting from high-throughput experiments pose previously unprecedented problem, creating an increasing demand for innovative ...
Colorectal cancer biomarker discovery and validation using LC-MS/MS-based proteomics in blood: truth or dare? Hasselt University University of Antwerp KU Leuven
Globally, colorectal cancer (CRC) is the third most common malignant neoplasm. However, highly sensitive, specific, noninvasive tests that allow CRC diagnosis at an early stage are still needed. As circulatory blood reflects the physiological status of an individual and/or the disease status for several disorders, efforts have been undertaken to identify candidate diagnostic CRC markers in plasma and serum. In this review, the challenges, ...
Review: Opportunities and barriers for omics-based biomarker discovery in steatotic liver diseases. KU Leuven
The rising prevalence of liver diseases related to obesity and excessive use of alcohol is fuelling an increasing demand for accurate biomarkers aimed at community screening, diagnosis of steatohepatitis and significant fibrosis, monitoring, prognosis and prediction of treatment efficacy. Breakthroughs in omics methodologies and the power of bioinformatics have created an excellent opportunity to combine clinical needs with technological ...
Biomarker discovery for personalized therapy selection in inflammatory bowel diseases: Challenges and promises. KU Leuven
The past decades witnessed a significant stride in deciphering the pathophysiology of inflammatory bowel disease, which further advanced drug development adding several new biologicals and small molecules to the arsenal of available therapies. Surprisingly, this wealth in therapeutic options did not yield the aspired high durable response rates. In addition, the increase in therapeutic availabilities ignited an increase in research toward ...
Assessing the suitability of capillary electrophoresis-mass spectrometry for biomarker discovery in plasma-based metabolomics Vrije Universiteit Brussel
The actual utility of capillary electrophoresis-mass spectrometry (CE-MS) for biomarker discovery using metabolomics still needs to be assessed. Therefore, a simulated comparative metabolic profiling study for biomarker discovery by CE-MS was performed, using pooled human plasma samples with spiked biomarkers. Two studies have been carried out in this work. Focus of study I was on comparing two sets of plasma samples, in which one set (class ...
Determination of variability due to biological and technical variation in urinary extracellular vesicles as a crucial step in biomarker discovery studies University of Antwerp
Urinary extracellular vesicles (EVs) are an attractive source of biomarkers for urological diseases. A crucial step in biomarker discovery studies is the determination of the variation parameters to perform a sample size calculation. In this way, a biomarker discovery study with sufficient statistical power can be performed to obtain biologically significant biomarkers. Here, a variation study was performed on both the protein and lipid content ...