Publications
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Chromosome scale assembly of the genome sequences of malus x domestica (apple) and Pyrus communis (European pear) Ghent University
Chromosome studies of a fertile mammalian hybrid: the offspring of the Cross Bongo X sitatunga (Bovoidea) Institute of Tropical Medicine
Social cognition and underlying cognitive mechanisms in children with an extra X chromosome: a comparison with autism spectrum disorder KU Leuven
Individuals with an extra X chromosome are at increased risk for autism symptoms. This study is the first to assess theory of mind and facial affect labeling in children with an extra X chromosome. Forty-six children with an extra X chromosome (29 boys with Klinefelter syndrome and 17 girls with Trisomy X), 56 children with autism spectrum disorder (ASD) and 88 non-clinical controls, aged 9-18 years, were included. Similar to children with ASD, ...
X chromosomal mutations and spermatogenic failure Vrije Universiteit Brussel
The X and Y chromosomes, the sex chromosomes, are important key players in germ cell development. Both chromosomes contain genes that are uniquely expressed in male spermatogenesis. Furthermore, these chromosomes are special because men only have a single copy of them. These features make the sex chromosomes interesting for studying in view of spermatogenesis defects. The role of the Y chromosome, together with the presence of Yq microdeletions, ...
Chromosome Painting Facilitates Anchoring Reference Genome Sequence to Chromosomes In Situ and Integrated Karyotyping in Banana (Musa Spp.) KU Leuven
Oligo painting FISH was established to identify all chromosomes in banana (Musa spp.) and to anchor pseudomolecules of reference genome sequence of Musa acuminata spp. malaccensis "DH Pahang" to individual chromosomes in situ. A total of 19 chromosome/chromosome-arm specific oligo painting probes were developed and were shown to be suitable for molecular cytogenetic studies in genus Musa. For the first time, molecular karyotypes of diploid M. ...
Molecular cytogenetic characterization of two cases with de novo small mosaic supernumerary marker chromosomes derived from chromosome 16: towards a genotype/phenotype correlation KU Leuven
Small supernumerary marker chromosomes (sSMC) derived from chromosome 16 are rare and, so far, it is not yet clear which regions of chromosome 16 are critical and have clinical consequences. We have characterized two cases with a ring-shaped sSMC derived from chromosome 16. In case A the sSMC was encountered prenatally and was characterized using centromeric fluorescence in situ hybridization (FISH) probes, subcentromere-specific multicolor FISH ...