Publications
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The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals Flanders Institute for Biotechnology KU Leuven
Function, diversity and therapeutic potential of the N-terminal domain of human chemokine receptors Vrije Universiteit Brussel
Chemokines and their receptors play fundamental roles in many physiological and pathological processes such as leukocyte trafficking, inflammation, cancer and HIV-1 infection. Chemokine-receptor interactions are particularly intricate and therefore require precise orchestration. The flexible N-terminal domain of human chemokine receptors has regularly been demonstrated to hold a crucial role in the initial recognition and selective binding of ...
Conserved negative charges in the N-terminal tetramerization domain mediate efficient assembly of Kv2.1 and Kv2.1/Kv6.4 channels Ghent University University of Antwerp
Voltage-gated potassium (Kv) channels are transmembrane tetramers of individual alpha-subunits. Eight different Shaker-related Kv subfamilies have been identified in which the tetramerization domain T1, located on the intracellular N terminus, facilitates and controls the assembly of both homo- and heterotetrameric channels. Only the Kv2 alpha-subunits are able to form heterotetramers with members of the silent Kv subfamilies (Kv5, Kv6, Kv8, and ...
Downregulation of 5-HT7 serotonin receptors by the atypical antipsychotics clozapine and olanzapine: role of motifs in the C-terminal domain and interaction with GASP-1 Ghent University
The human 5-HT7 serotonin receptor, a G-protein-coupled receptor (GPCR), activates adenylyl cyclase constitutively and upon agonist activation. Biased ligands differentially activate 5-HT7 serotonin receptor desensitization, internalization and degradation in addition to G protein activation. We have previously found that the atypical antipsychotics clozapine and olanzapine inhibited G protein Lysosome activation and, surprisingly, induced both ...
The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA editing ligase L2 Vrije Universiteit Brussel
Trypanosomatids, such as the sleeping sickness parasite Trypanosoma brucei, contain a ?20S RNA-editing complex, also called the editosome, which is required for U-insertion/deletion editing of mitochondrial mRNAs. The editosome contains a core of 12 proteins including the large interaction protein A1, the small interaction protein A6, and the editing RNA ligase L2. Using biochemical and structural data, we identified distinct domains of T. ...
PEX5 binds monomeric catalase blocking its tetramerization, and releases it upon binding the N-terminal domain of PEX14 KU Leuven
Newly synthesized peroxisomal matrix proteins are targeted to the organelle by PEX5. PEX5 has a dual role in this process. First, it acts as a soluble receptor recognizing these proteins in the cytosol. Subsequently, at the peroxisomal docking/translocation machinery, PEX5 promotes their translocation across the organelle membrane. Despite significant advances made in recent years, several aspects of this pathway remain unclear. Two important ...
The N-terminal domain of the Flo11 protein from Saccharomyces cerevisiae is an adhesin without mannose binding activity. Vrije Universiteit Brussel
The expression of the Flo11 flocculin in Saccharomyces cerevisiae offers the cell a wide range of phenotypes, depending on the strain and the environmental conditions. The most important are pseudohyphae development, invasive growth and flocculation. The mechanism of cellular adhesion mediated by Flo11p is not well understood. Therefore, the N-terminal domain of Flo11p was purified and studied. Although its amino acid sequence shows less ...
Heterozygous mutations in the C-terminal domain of COPA underlie a complex autoinflammatory syndrome. KU Leuven Flanders Institute for Biotechnology
Mutations in the N-terminal WD40 domain of coatomer protein complex subunit α (COPA) cause a type I interferonopathy, typically characterized by alveolar hemorrhage, arthritis, and nephritis. We described 3 heterozygous mutations in the C-terminal domain (CTD) of COPA (p.C1013S, p.R1058C, and p.R1142X) in 6 children from 3 unrelated families with a similar syndrome of autoinflammation and autoimmunity. We showed that these CTD COPA mutations ...
The N-terminal domain of the Flo1 flocculation protein from Saccharomyces cerevisiae binds specifically to mannose carbohydrates Vrije Universiteit Brussel
Saccharomyces cerevisiae cells possess a remarkable capacity to adhere to other yeast cells, which is called
flocculation. Flocculation is defined as the phenomenon wherein yeast cells adhere in clumps and sediment
rapidly from the medium in which they are suspended. These cell-cell interactions are mediated by a class of
specific cell wall proteins, called flocculins, that stick out of the cell walls of flocculent cells. The ...
flocculation. Flocculation is defined as the phenomenon wherein yeast cells adhere in clumps and sediment
rapidly from the medium in which they are suspended. These cell-cell interactions are mediated by a class of
specific cell wall proteins, called flocculins, that stick out of the cell walls of flocculent cells. The ...