Publications

Epidermal growth factor receptor (EGFR) gene copy number evaluated by fluorescence in situ hybridisation (FISH) can discriminate among KRAS wild-type patients those with better outcome to EGFR-targeted therapy in metastatic colorectal cancer, further enhancing selection of patients. Nevertheless, enumeration of gene copies is challenging and the lack of analytical standardisation has limited incorporation of the test into the clinical practice. ...

We investigated the reproducibility of the major statistical conclusions drawn in 46 articles published in 2012 in three APA journals. After having identified 232 key statistical claims, we tried to reproduce, for each claim, the test statistic, its degrees of freedom, and the corresponding p value, starting from the raw data that were provided by the authors and closely following the Method section in the article. Out of the 232 claims, we were ...

The brewing industry, suppliers and universities have pilot breweries with different sizes and varying requirements to study technological or raw material related questions. Thereby the reproducibility of the brewing system as well as of the analytical evaluation of the samples drawn have to be payed closer attention to. This study describes the methodology and results of a reproducibility investigation on a 2hl pilot plant with particular focus ...

The good reproducibility of the 2 hl research brewery as proven in our previous study has been now reviewed after storing the beers at 0 °C and deep frozen (at – 24 °C) for 240 days. Except for some Strecker aldehydes all other ageing aldehydes, fermentation by-products and particularly the analyzed hop aroma compounds show good stability at 0 °C. The analytical standard deviations of the three-fold determinations are even a little lower than ...

INTRODUCTION: Graph metrics have been proposed as potential biomarkers for diagnosis in clinical work. However, before it can be applied in a clinical setting, their reproducibility should be evaluated. METHODS: This study systematically investigated the effect of two denoising pipelines and different whole-brain network constructions on reproducibility of subject-specific graph measures. We used the multi-session fMRI dataset from the Brain ...

In Europe, in situ measurements of sound reflection and airborne sound insulation of noise barriers are usuallydone according to CEN/TS 1793-5. This method has been improved substantially during the EU funded QUIESST collaborative project. Within the same framework, an inter-laboratory test has been carried out to assess the repeatability and reproducibility of the newly developed method when applied to real-life samples, including the effect of ...

In our group, we work on the surface modification of cellulose nanocrystals. During this work, we have encountered reproducibility issues when the same reactions were performed on nanocrystals from different hydrolysis batches, indicating a variable surface composition. Given the inherent purity of the nanoparticles themselves, this issue was believed to be due to the presence of adsorbed species at the surface of the nanocrystals blocking ...

The analysis of fish age data is vital for the successful conservation of fish. Attempts to develop optimal management strategies for effective conservation of the endemic Labeobarbus species are strongly affected by the lack of accurate age estimates. Although methodological studies are key to acquiring a good insight into the age of fishes, up to now, there have not been any studies comparing different methods for these species. Thus, this ...