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Educational impact of discussing results among nuclear medicine physicians participating in interobserver reproducibility studies : our experience with I-123 FP-CIT SPECT Ghent University

Marianne Tondeur, Anne-Sophie Hambye, Alain San, Hamphrey Ham
Objectives In nuclear medicine, reproducibility studies allow the assessment of the robustness of a technique. They could also be used in continuing education. This study evaluates this educational impact. Methods Two series of clinical data and I-123 fluoropropyl-carbomethoxy-iodophenyl-nortropane single photon emission tomography images from 12 patients were prepared before initiating the study. Each series covered similarly a wide spectrum of ...

A multicenter study to assess the reproducibility of antiphospholipid antibody results produced by an automated system Ghent University

Katrien Devreese, A Poncet, E Lindhoff-Last, J Musial, P de Moerloose, P Fontana
Background: Inter-assay variability is a well-known problem in antiphospholipid antibody testing, because of the lack of standardization. Inter-laboratory reproducibility for the same assay is similarly important. Objectives: Testing repeatability and reproducibility of HemosIL((R)) AcuStar for anticardiolipin (aCL) and anti2-glycoprotein I antibodies (a2GPI) IgG and IgM. Patients/Methods: In this observational study, out of 420 samples from the ...

Standardisation of EGFR FISH in colorectal cancer: results of an international interlaboratory reproducibility ring study KU Leuven

Steffen Fieuws, Sara Vander Borght, Sabine Tejpar
Epidermal growth factor receptor (EGFR) gene copy number evaluated by fluorescence in situ hybridisation (FISH) can discriminate among KRAS wild-type patients those with better outcome to EGFR-targeted therapy in metastatic colorectal cancer, further enhancing selection of patients. Nevertheless, enumeration of gene copies is challenging and the lack of analytical standardisation has limited incorporation of the test into the clinical practice. ...

The reproducibility of statistical results in psychological research: An investigation using unpublished raw data. KU Leuven

Richard Artner, Frits Traets, Francis Tuerlinckx, Wolf Vanpaemel
We investigated the reproducibility of the major statistical conclusions drawn in 46 articles published in 2012 in three APA journals. After having identified 232 key statistical claims, we tried to reproduce, for each claim, the test statistic, its degrees of freedom, and the corresponding p value, starting from the raw data that were provided by the authors and closely following the Method section in the article. Out of the 232 claims, we were ...

Reproducibility of the Kinematics in Rotational High-Velocity, low-amplitude thrust of the upper cervical spine: a cadaveric study Vrije Universiteit Brussel

Silvia Gianola, Erik Cattrysse, Steven Provyn, Peter Van Roy
Objective: this study aimed to investigate the reproducibility of the kinematics in rotational high-velocity, low-amplitude (HVLA) thrust of the upper cervical spine.
Methods: twenty fresh human cervical specimens were studied in a test-retest situation with 2 manual therapists. Kinematics of C1-C2 and C0-C1 were examined during segmental rotational HVLA manipulation through an ultrasound-based tracking system. The thrust moment was ...

Kinetic modeling and long-term test-retest reproducibility of the mGluR5 PET tracer 18F-FPEB in human brain Vrije Universiteit Brussel KU Leuven University of Antwerp

Gil Leurquin-Sterk, Andrey Postnov, Bart de Laat, Cindy Casteels, Sofie Celen, Cleo Crunelle, Guy Bormans, Michel Koole, Koen Van Laere

(18)F-FPEB is a promising PET tracer for studying the metabotropic glutamate subtype 5 receptor (mGluR5) expression in neuropsychiatric disorders. To assess the potential of (18)F-FPEB for longitudinal mGluR5 evaluation in patient studies, we evaluated the long-term test-retest reproducibility using various kinetic models in the human brain. Nine healthy volunteers underwent consecutive scans separated by a 6-month period. Dynamic PET was ...

Reproducibility of 20-min Time-trial Performance on a Virtual Cycling Platform Vrije Universiteit Brussel

Guilherme Matta, Andrew Edwards, Bart Roelands, Florentina Hettinga

This study aimed to analyse the reproducibility of mean power output during 20-min cycling time-trials, in a remote home-based setting, using the virtual-reality cycling software, Zwift. Forty-four cyclists (11 women, 33 men; 37±8 years old, 180±8 cm, 80.1±13.2 kg) performed 3×20-min time-trials on Zwift, using their own setup. Intra-class correlation coefficient (ICC), coefficient of variation (CV) and typical error (TE) were calculated for ...

Repeatability and reproducibility of ADC measurements Vrije Universiteit Brussel

Nicolas F Michoux, Jakub Wladyslaw Ceranka, Jef Vandemeulebroucke, Frank Peeters, Pierre Lu, Julie Absil, Perrine Triqueneaux, Laurence Collette, Inneke Willekens, Carola Brussaard, et al.

OBJECTIVES: Multicenter oncology trials increasingly include MRI examinations with apparent diffusion coefficient (ADC) quantification for lesion characterization and follow-up. However, the repeatability and reproducibility (R&R) limits above which a true change in ADC can be considered relevant are poorly defined. This study assessed these limits in a standardized whole-body (WB)-MRI protocol.

METHODS: A prospective, multicenter ...

Reproducibility and symptomatic predictors of a slow nutrient drinking test in health and in functional dyspepsia Vrije Universiteit Brussel KU Leuven

Sébastien Kindt, B Coulie, E Wajs, J Janssens, J Tack

Impaired accommodation to a meal has been recognized as a pathophysiological mechanism in functional dyspepsia (FD). Based on observations in tertiary care patients, the drinking test has been proposed as a non-invasive tool to estimate accommodation. Our aim was to assess the reproducibility of the drinking test and its correlation with demographic, symptomatic and pathophysiological parameters in secondary care FD patients and healthy ...