Projects
Role of angiogenesis and angiogenic growth factors (VEGF, PLGF) in portal hypertension and fibrosis formation in animal models of cirrhosis, steatosis and portal hypertension Ghent University
Models of portal hypertension and cirrhosis are used to study prevention and reversibility of collateral formation (in peripheral, splanchnic and pulmonary area), by treating mice with anti-PLGF and by using PLGF knock-out mice. Fibrosis formation and the role of hepatic stellate cells in the angiogenesis setting will be studied. In mice models of NASH will be the role of angiogenesis in fibrosis and colalteral formation studied in different ...
Role of angiogenesis and angiogenetic growth factors (VEGF, PLGF) in portal hypertension and fibrosis formation in animal models of cirrhosis, steatosis and portal hypertension. Ghent University
Models of portal hypertension and cirrhosis are used to study prevention and reversibility of collateral formation (in peripheral, splanchmic and pulmonary area), by treating mice with anti-PLGF and by using PLGF knock-out mice. Fibrosis formation and the role of hepatic stellate cells in the angiogenesis setting will be studied. In mice models of NASH will be the role of angiogenesis in fibrosis and collateral formation studied in different ...
Unraveling the specifics of Portal Hypertension in Non-Alcoholic Steatohepatitis and its role in disease progression. University of Antwerp
Stratifying risk and individualizing care for patients with clinically significant portal hypertension (CSPH) KU Leuven
Stratifying risk and individualizing care for patients with clinical significant portal hypertension (CSPH) PhD candidate: Emma Vanderschueren, MD PhD promotor: Wim Laleman, MD PhD, CHROMETA Cirrhosis is the eventual and unavoidable consequence of any given protracted active chronic liver disease, like e.g. hepatitis B, hepatitis C, (non) alcoholic fatty liver disease,... When the underlying liver disease is left untreated, (asymptomatic) ...
Role of ER stress in the angiogenesis associated with liver cirrhosis and portal hypertension Ghent University
Models of portal hypertension and cirrhosis are used to study the role of ER stress in the development of angiogenesis and fibrosis in the liver and splanchnic circulation. We hypothesize that in PHT and cirrhosis, strategies inhibiting ER stress (by using silencing RNAU+2019s or JIK/Tao3K knockout mice) can decrease inflammation and hypoxia leading to less angiogenesis and fibrosis formation. But that on the other hand, strategies ...