Publications
Synthesis of novel Ziegler Natta catalyst in the presence of internal promoter and electron donors for ethylene and ethylene/ 1-hexene polymerization Ghent University
BRCA1 and BRCA2 5U+2032 noncoding region variants identified in breast cancer patients alter promoter activity and protein binding Ghent University
DFNA5 promoter methylation a marker for breast tumorigenesis Vrije Universiteit Brussel University of Antwerp
BACKGROUND: Identification of methylation markers that are sensitive and specific for breast cancer may improve early detection. We hypothesize that DFNA5 promoter methylation can be a valuable epigenetic biomarker, based upon strong indications for its role as tumor suppressor gene and its function in regulated cell death.
RESULTS: Statistically different levels of methylation were seen, with always very low levels in healthy breast ...
Promoter analysis for three types of EUL-related rice lectins in transgenic Arabidopsis Ghent University
Excision of a selectable marker gene in transgenic banana using a Cre/lox system controlled by an embryo specific promoter Vrije Universiteit Brussel
powerful selection tools. Nonetheless, once transgenic events have been obtained
their presence is no longer needed and can even be undesirable. In this work, we have
developed a system to excise the selectable marker and the cre recombinase genes
from transgenic banana cv. 'Grande Naine' (Musa AAA). To achieve this, the embryo
...
Promoter knock-in: a novel rational method for the fine tuning of genes. Vrije Universiteit Brussel
Characterization of position-induced spatial and temporal regulation of transgene promoter activity in plants Research Institute for Agriculture, Fisheries and Food
Quantitative differences in transgene expression between independent transformants are generally ascribed to different integration sites of the transgene (position effect). The contribution of spatial and temporal changes in transgene promoter activity to these position-induced differences in transgene expression in planta are characterized, using the firefly luciferase (luc) reporter system. The activity of three different promoters ...
Promoter DNA methylation regulates progranulin expression and is altered in FTLD Vrije Universiteit Brussel University of Antwerp
BACKGROUND: Frontotemporal lobar degeneration (FTLD) is a heterogeneous group of neurodegenerative diseases associated with personality changes and progressive dementia. Loss-of-function mutations in the growth factor progranulin (GRN) cause autosomal dominant FTLD, but so far the pathomechanism of sporadic FTLD is unclear.
RESULTS: We analyzed whether DNA methylation in the GRN core promoter restricts GRN expression and, thus, might ...
Guanosine triphosphate cyclohydrolase 1 promoter deletion causes dopa-responsive dystonia Vrije Universiteit Brussel University of Antwerp
BACKGROUND: Autosomal dominant dopa-responsive dystonia (AD-DRD) is caused by a biochemical defect primarily resulting from guanosine triphosphate cyclohydrolase 1 gene (GCH1) mutations. Few families have been reported without mutations in GCH1.
METHODS: Genome-wide linkage analysis and positional cloning to identify the genetic defect in a Belgian AD-DRD family was carried out.
RESULTS AND CONCLUSION: In this study, we report on ...